False memories prime immune system for future attacks

IN A police line-up, a falsely remembered face is a big problem. But for the body's police force – the immune system – false memories could be a crucial weapon.

When a new bacterium or virus invades the body, the immune system mounts an attack by sending in white blood cells called T-cells that are tailored to the molecular structure of that invader. Defeating the infection can take several weeks. However, once victorious, some T-cells stick around, turning into memory cells that remember the invader, reducing the time taken to kill it the next time it turns up.

Conventional thinking has it that memory cells for a particular microbe only form in response to an infection. "The dogma is that you need to be exposed," says Mark Davis of Stanford University in California, but now he and his colleagues have shown that this is not always the case.

The team took 26 samples from the Stanford Blood Center. All 26 people had been screened for diseases and had never been infected with HIV, herpes simplex virus or cytomegalovirus. Despite this, Davis's team found that all the samples contained T-cells tailored to these viruses, and an average of 50 per cent of these cells were memory cells.

The idea that T-cells don't need to be exposed to the pathogen "is paradigm shifting," says Philip Ashton-Rickardt of Imperial College London, who was not involved in the study. "Not only do they have capacity to remember, they seem to have seen a virus when they haven't."

So how are these false memories created? To a T-cell, each virus is "just a collection of peptides", says Davis. And so different microbes could have structures that are similar enough to confuse the T-cells.

To test this idea, the researchers vaccinated two people with an H1N1 strain of influenza and found that this also stimulated the T-cells to react to two bacteria with a similar peptide structure. Exposing the samples from the blood bank to peptide sequences from certain gut and soil bacteria and a species of ocean algae resulted in an immune response to HIV (Immunology, doi.org/kgg).

The finding could explain why vaccinating children against measles seems to improve mortality rates from other diseases. It also raises the possibility of creating a database of cross-reactive microbes to find new vaccination strategies. "We need to start exploring case by case," says Davis.

"You could find innocuous pathogens that are good at vaccinating against nasty ones," says Ashton-Rickardt. The idea of cross-reactivity is as old as immunology, he says. But he is excited about the potential for finding unexpected correlations. "Who could have predicted that HIV was related to an ocean algae?" he says. "No one's going to make that up!"

This article appeared in print under the headline "False memories prime our defences"

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6.2 quake shakes Philippines' Mindanao

MANILA: A powerful 6.2-magnitude earthquake rocked the southern Philippine island of Mindanao on Saturday triggering panic, but there were no immediate reports of any damage or casualties.

The quake struck at 12:37 pm (0437 GMT), off the coast, about 30 kilometres (19 miles) northeast of the town of Sarangani, said the government seismology institute.

Residents said people rushed out of buildings in panic after the quake sent lighting fixtures swaying.

The government institute said it did not expect any damage or casualties and there was no risk of a tsunami.

The Philippines sits on the Pacific Ring of Fire -- a belt around the Pacific Ocean dotted by active volcanoes and tectonic trenches.

A 7.6-magnitude quake hit the country's east coast in August last year, triggering a tsunami alert that forced tens of thousands to flee their homes and causing a landslide that killed one person.

- AFP/ck

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E-orders for 128GB Surface Pro to ship in 2-3 weeks -- Microsoft

Microsoft provided another update at the end of this week regarding the availability of its sold-out 128GB version of the Surface Pro.

A February 15 Surface Blog post said that those ordering through the Microsoft online store in the U.S. can place an order for the 128GB model and have it ship in two to three weeks.

The new post also provided updated information for those wanting to "reserve" the Intel-based PC/tablet hybrid
Surface Pro devices. Up until now, Microsoft officials have declined comment when asked whether users would be able to pre-order Surface Pros.

Here's the latest Surface Pro availability guidance:

At Best Buy (U.S.): Inventory levels are increasing and many Best Buy stores have Surface Pro units for sale in-store. If the store does not have stock, you can reserve a Surface Pro (64GB and 128GB). Please note that Best Buy is only taking reservations in their stores for Surface Pro based on new inventory they know is coming in next week, so it's possible that reservations could become "sold out."

At Staples (U.S.): Many Staples stores have Surface Pro units for sale in stores. If the store does not have stock, you can place a kiosk order in store to purchase Surface Pro 64GB for delivery.

For Canada: In Best Buy and Future Shop stores you can reserve the 64GB Surface Pro in stores at this time. Staples has availability online while inventory lasts and more inventory has been ordered to ensure store availability in the near future. More details to come on the 128GB Surface Pro availability in Canada.

It seems that Staples is making the 128GB Surface Pros available for order online and that they are not being stocked in Staples brick-and-mortar outlets, as I noted earlier this week.

Microsoft is "work(ing) around the clock to meet that demand with production and get new inventory into retail," the post concluded. Company officials advise customers interested in the Pros to call ahead before venturing to stores this weekend, in spite of guidance earlier in the week that more stores would have stock on hand starting on Saturday, February 16.

It's still unclear why there are not enough Surface Pros on the market. Is it that Microsoft seriously underestimated demand for 128GB Surface Pros -- a happy problem for the Softies? Or have supply-chain problems led to device shortages (a not-so-happy problem)? Microsoft's Surface Pro devices went on sale February 9.

This story originally appeared on ZDNet under the headline "Microsoft: Online orders for 128 GB Surface Pro to ship in two to three weeks."

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Severe Weather More Likely Thanks to Climate Change

Jane J. Lee

BOSTON—Wildfires. Droughts. Super storms.

As opposed to representing the unfortunate severe weather headlines of the last year, scientists said Friday that climate change has increased the likelihood of such events moving forward.

And though the misery is shared from one U.S. coast to another, scientists speaking at the annual American Association for the Advancement of Science meeting in Boston said, the type of extreme event may vary significantly from region to region. (Related: "6 Ways Climate Change Will Affect You.")

Heat waves have become more frequent across the United States, with western regions setting records for the number of such events in the 2000s, said Donald Wuebbles, a geoscientist with the University of Illinois at Urbana-Champaign.

But the Midwest and Northeast have experienced a 45 percent and 74 percent increase, respectively, in the heaviest rainfalls those regions have seen since 1950.

The extreme drought that plagued Texas in 2011 has spread to New Mexico, Louisiana, Oklahoma, and northern Mexico, said John Nielsen-Gammon, Texas State's climatologist at Texas A&M University in College Station.

"The science is clear and convincing that climate change is happening and it's happening rapidly. There's no debate within the science community ... about the changes occurring in the Earth's climate and the fact that these changes are occurring in response to human activities," said Wuebbles.

In 2011 and 2012, major droughts, heat waves, severe storms, tornadoes, floods, hurricanes, and wildfires caused about $60 billion in damages each year, for a total of about $120 billion.

According to the National Oceanic and Atmospheric Administration Climactic Data Center, these were some of the costliest weather events in the country's history, said Wuebbles.

President Obama argued in his State of the Union address this week that the time is ripe to address climate change, saying he would skirt Congress to make such changes, if necessary.

His proposals included a system similar to the cap-and-trade proposal killed in Congress during his first term, new regulations for coal-burning power plants, and a promise to promote energy efficiency and R&D efforts into cleaner technologies. (Related: "Obama Pledges U.S. Action on Climate, With or Without Congress.")

The researchers said they are glad to see that addressing climate change is on the President's agenda. But they stressed that they wanted the public to have access to accurate, scientifically sound information, not just simplified talking points.

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Carnival Cruise Ship Hit With First Lawsuit

The first lawsuit against Carnival Cruise Lines has been filed and it is expected to be the beginning of a wave of lawsuits against the ship's owners.

Cassie Terry, 25, of Brazoria County, Texas, filed a lawsuit today in Miami federal court, calling the disabled Triumph cruise ship "a floating hell."

"Plaintiff was forced to endure unbearable and horrendous odors on the filthy and disabled vessel, and wade through human feces in order to reach food lines where the wait was counted in hours, only to receive rations of spoiled food," according to the lawsuit, obtained by ABCNews.com. "Plaintiff was forced to subsist for days in a floating toilet, a floating Petri dish, a floating hell."

Click Here for Photos of the Stranded Ship at Sea

The filing also said that during the "horrifying and excruciating tow back to the United States," the ship tilted several times "causing human waste to spill out of non-functioning toilets, flood across the vessel's floors and halls, and drip down the vessel's walls."

Terry's attorney Brent Allison told ABCNews.com that Terry knew she wanted to sue before she even got off the boat. When she was able to reach her husband, she told her husband and he contacted the attorneys.

Allison said Terry is thankful to be home with her husband, but is not feeling well and is going to a doctor.

Carnival's Triumph Passengers: 'We Were Homeless' Watch Video

Girl Disembarks Cruise Ship, Kisses the Ground Watch Video

Carnival Cruise Ship Passengers Line Up for Food Watch Video

"She's nauseated and actually has a fever," Allison said.

Terry is suing for breach of maritime contract, negligence, negligent misrepresentation and fraud as a result of the "unseaworthy, unsafe, unsanitary, and generally despicable conditions" on the crippled cruise ship.

"Plaintiff feared for her life and safety, under constant threat of contracting serious illness by the raw sewage filling the vessel, and suffering actual or some bodily injury," the lawsuit says.

Despite having their feet back on solid ground and making their way home, many passengers from the cruise ship are still fuming over their five days of squalor on the stricken ship and the cruise ship company is likely to be hit with a wave of lawsuits.

"I think people are going to file suits and rightly so," maritime trial attorney John Hickey told ABCNews.com. "I think, frankly, that the conduct of Carnival has been outrageous from the get-go."

Hickey, a Miami-based attorney, said his firm has already received "quite a few" inquiries from passengers who just got off the ship early this morning.

"What you have here is a) negligence on the part of Carnival and b) you have them, the passengers, being exposed to the risk of actual physical injury," Hickey said.

The attorney said that whether passengers can recover monetary compensation will depend on maritime law and the 15-pages of legal "gobbledygook," as Hickey described it, that passengers signed before boarding, but "nobody really agrees to."

One of the ticket conditions is that class action lawsuits are not allowed, but Hickey said there is a possibility that could be voided when all the conditions of the situation are taken into account.

One of the passengers already thinking about legal action is Tammy Hilley, a mother of two, who was on a girl's getaway with her two friends when a fire in the ship's engine room disabled the vessel's propulsion system and knocked out most of its power.

"I think that's a direction that our families will talk about, consider and see what's right for us," Hilley told "Good Morning America" when asked if she would be seeking legal action.

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Sand-grain-sized drum extends reach of quantum theory

The banging of a tiny drum heralds the intrusion of the weird world of quantum mechanics into our everyday experience. Though no bigger than a grain of sand, the drum is the largest object ever to have been caught obeying the uncertainty principle, a central idea in quantum theory.

As well as extending the observed reach of quantum theory, the finding could complicate the hunt for elusive gravitational waves : it suggests that the infinitesimal motion caused by these still-hypothetical ripples in spacetime could be overwhelmed by quantum effects.

The uncertainty principle says that you cannot simultaneously determine both a particle's exact position and momentum. For example, bouncing a photon off an electron will tell you where it is, but it will also change the electron's motion, creating fresh uncertainty in its speed.

This idea limits our ability to measure the properties of very small objects, such as electrons and atoms. The principle should also apply to everyday, macroscopic objects, but this has not been tested – for larger objects, the principle's effects tend to be swamped by other uncertainties in measurement, due to random noise, say.

Quantum drum

To extend the known reach of the uncertainty principle, Tom Purdy and colleagues of the University of Colorado, Boulder, created a drum by tightly stretching a 40-nanometre-thick sheet of silicon nitride over a square frame with sides of half a millimetre – about the width of a grain of sand. They placed the drum inside a vacuum chamber cooled to a few degrees above absolute zero, minimising any interference by random noise.

By continuously firing a stream of photons at the drum they were able to get increasingly precise measurements of the position of the skin at any moment. However, this also caused the skin to vibrate at an unknown speed. When they attempted to determine its momentum, the error in their measurement had increased – just as the uncertainty principle predicts.

"You don't usually have to think about quantum mechanics for objects you can hold in your hand," says Purdy.

That the uncertainty principle holds sway at such a large scale could affect the hunt for gravitational waves, which are predicted by Einstein's theory of general relativity but have never been detected.

Mitigation strategy

Gravitational wave detectors look for very slight changes in the distance between two test masses caused by passing spacetime ripples. Purdy says his team's experiment confirms long-held suspicions that quantum uncertainty could overwhelm these very small changes.

Now he and others can use the drum to explore more advanced measurement techniques to mitigate the effects. For example, uncertainty in an object's momentum could lead to future uncertainty in its position and there should be ways to minimise such knock-on effects. "You can't avoid the uncertainty principle, but you can in some clever ways make it [such that] increasing the momentum doesn't add back to the uncertainty in position at a later time," says Purdy.

His experiment is a neat demonstration of the breakdown of the traditional notion that the atomic world is quantum while the macroscopic world is classic, says Gerard Milburn of the University of Queensland in Brisbane, Australia, who was not involved in the work. Previous, attempts to blur the quantum-classical divide have involved entangling diamonds and demonstrating quantum superposition in a strip of metal.

Despite these feats, Milburn doesn't rule out the prospect of a breakdown on really large scales. "Of course maybe one day we will see quantum mechanics fail at some scale. Testing it to destruction is a good motivation for going down this path," he says.

Journal reference: Science, DOI: 10.1126/science.1231282

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Experts tell flatulent flyers: let it rip

WELLINGTON: A group of medical specialists has provided an answer to a dilemma that has faced flyers since the Wright brothers took to the air in 1903 -- is it okay to fart mid-flight?

The experts' recommendation is an emphatic yes to airline passengers -- but a warning to cockpit crews that breaking wind could distract the pilot and pose a safety risk.

The study concluded that anecdotal evidence that flying increases flatulence is not hot air, finding that changes in air pressure at altitude result in the gut producing more gas.

When Danish gastroenterologist Jacob Rosenberg encountered the malodorous problem first-hand on a flight from Copenhagen to Tokyo, he enlisted some of the finest minds in his field to address the issue.

The result was an in-depth review of scientific literature on flatulence, looking at issues such as whether women's farts smell worse than men's (yes), what causes the odour (sulphur) and how often the average person passes wind every day (10 times).

The bottom line, according to the 3,000-word study published in the New Zealand Medical Journal on Friday, is that airline passengers should ignore the social embarrassment of breaking wind and "just let it go".

"(Holding back) holds significant drawbacks for the individual, such as discomfort and even pain, bloating, dyspepsia (indigestion), pyrosis (heartburn) just to name but a few resulting abdominal symptoms," the study found.

"Moreover, problems resulting from the required concentration to maintain such control may even result in subsequent stress symptoms."

The authors -- five gastroenterologists from Denmark and Britain -- said that while passengers may experience poor service from the cabin crew as a result of their decision, the health benefits outweighed any negative impacts.

However, they said the cockpit crew faced a lose-lose situation.

"On the one hand, if the pilot restrains a fart, all the drawbacks previously mentioned, including impaired concentration, may affect his abilities to control the plane," the researchers said.

"On the other hand, if he lets go of the fart, his co-pilot may be affected by its odour, which again reduces safety onboard the flight."

The authors canvassed a number of solutions to the issue of flight-induced flatulence, including using methane breath tests to screen wind-prone passengers from flights, but rejected them as impractical.

They did, however, note that the textile covers used on seats in economy class absorbed up to 50 percent of odours because they are gas permeable, unlike the leather seats in first class.

They suggested airlines could improve the odour-eating properties of the seats and issue special blankets and trousers to passengers to minimise mid-air flatulence.

"We humbly propose that active charcoal should be embedded in the seat cushion, since this material is able to neutralise the odour," they said.

"Moreover active charcoal may be used in trousers and blankets to emphasise this effect."

Air New Zealand declined to comment when asked if it would adopt such measures.

- AFP/fl

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HTC flagship One expected to debut in U.S. on March 22

HTC's new One is expected to closely resemble the Droid DNA.

(Credit:
CBS Interactive)

The HTC One, expected to be the Taiwanese smartphone maker's next flagship handset, is set to launch in the U.S. on March 22, according to a report on HTC Source .

Formerly code named M7, the HTC One with 32GB of storage will debut on AT&T, T-Mobile, and Sprint for $199.99 with a two-year contract, unnamed sources tell the blog. A 64GB model will sell for $299.99.

Earlier reports held that the handset would debut in Europe on March 8.

The new device is expected to sport a 4.7-inch 1080p HD display, a 1.7GHz quad-core processor, an infrared port up top, and front-facing stereo speakers housed in a metal case. Other reports held that the device would be
Android powered and feature a quad-core Qualcomm S4 Pro processor and a 13-megapixel camera.

CNET has contacted HTC for comment and will update this report when we learn more.

The device might be unveiled at a February 19 event, from which CNET providing first-hand accounts and early impressions of the new device.

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Why We Walk … and Run … And Walk Again to Get Where We're Going

You have to get to a bus stop to catch the once-an-hour express ... or to a restaurant to meet a friend ... or to a doctor's office. You've got maybe a half a mile to cover and you're worried you'll be late. You run, then you stop and walk, then run some more.

But wait. Wouldn't it be better to run the whole way?

Not necessarily.

A new study by an assistant professor of mechanical engineering at Ohio State University tests the theory that people subconsciously mix walking and running so they get where they need to. The idea is that "people move in a manner that minimizes energy consumption," said the professor, Manoj Srinivasan.

Srinivasan asked 36 subjects to cover 400 feet (122 meters), a bit more than the length of a football field. He gave them a time to arrive at the finish line and a stopwatch. If the deadline was supertight, they ran. If they had two minutes, they walked. And if the deadline was neither too short nor too far off, they toggled between walking and running.

The takeaway: Humans successfully make the walk-run adjustment as they go along, based on their sense of how far they have to go. "It's not like they decide beforehand," Srinivasan said. (Get tips, gear recommendations, and more in our Running Guide.)

The Best Technique for "the Twilight Zone"

"The mixture of walking and running is good when you have an intermediate amount of time," he explained. "I like to call it 'the Twilight Zone,' where you have neither infinite time nor do you have to be there now."

That ability to shift modes served ancient humans well. "It's basically an evolutionary argument," Srinivasan said. A prehistoric human seeking food would want to move in a way that conserves some energy so that if food is hard to find, the hunter won't run out of gas—and will still be able to rev it up to escape predators.

The study, published on January 30 in the Journal of the Royal Society Interface, doesn't answer that question of how we make such adjustments.

Runners: Take a Break if You Need It

The mix of walking and running is also something that nonelite marathoners are familiar with. Covering 26.2 miles might take less of a toll if the runner stops running from time to time, walks a bit, then resumes a jogging pace. "You use less energy overall and also give yourself a bit of a break," Srinivasan noted. (Watch: An elite marathoner on her passion for running.)

One take-home lesson is: Runners, don't push it all the time. A walk-run mix will minimize the energy you expend.

Lesson two: If you're a parent walking with your kid, and the kid lags behind, then runs to catch up, then lags again, the child isn't necessarily trying to annoy you. Rather, the child is perhaps exhibiting an innate ability to do the walk-run transition.

Potential lesson three: The knowledge that humans naturally move in a manner that minimizes energy consumption might be helpful in designing artificial limbs that feel more natural and will help the user reduce energy consumption.

The big question for Manoj Srinivasan: Now that he has his walk-run theory, does he consciously switch between running and walking when he's trying to get somewhere? "I must admit, no," he said. "When I want to get somewhere, I just let the body do its thing." But if he's in a rush, he'll make a mad dash.

"Talk to you tomorrow," he signed off in an email to National Geographic News. "Running to get to teaching now!"

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Nightmare Ends: Passengers Leave Disabled Ship

The ordeal of the disabled Carnival Triumph cruise ship carrying 4,000 passengers and crew appeared to be almost over, with people starting to disembark in Mobile, Ala., after days at sea without power in often squalid conditions.

After the ship arrived at port around 9:30 p.m. local time (10:30 p.m. ET), Carnival president and CEO Gerry Cahill praised the ship's crew and told reporters that he was headed on board to apologize directly to its passengers.

Passengers appeared to begin disembarking around 10:15 p.m. CT (11:15 p.m. ET).

The Carnival Triumph departed Galveston, Texas, Thursday and lost power Sunday after a fire in the engine room disabled the vessel's propulsion system and knocked out most of its power.

After power went out, passengers texted ABC News that sewage was seeping down the walls from burst plumbing pipes, carpets were wet with urine, and food was in short supply. Reports surfaced of elderly passengers running out of critical heart medicine and others on board squabbling over scarce food.

"I know the conditions on board were very poor," Cahill said. "I know it was very difficult, and I want to apologize again for subjecting our guests for that. ... Clearly, we failed in this particular case."

It could take up to five hours to get everybody off the huge ship.

"Inside the terminal, there's also warm food available," said Terry Thornton, Carnival's senior vice president of marketing. "There are blankets, there are cell phones and refreshments available for the guests that need that or want that assistance.

Passengers will have the options of boarding buses to Houston or Galveston, Texas, about seven hours away, or New Orleans, about two hours away, officials said.

"We have gotten our guests back to land," Cahill said. "Now, we need to get them home. ... The full resources of Carnival are working from here to get them home as quickly as we possibly can."

Stranded Carnival Cruise Ship On Its Way to Port Watch Video

Carnival Cancels All Scheduled Voyages Aboard the Triumph Watch Video

Carnival Cruise Ship Making Its Way to Port Watch Video

At an earlier news conference this afternoon, Thornton said that anyone with special needs and children will be the first to get off the boat. He said the company's No. 1 priority is to make the process as "quick, efficient and comfortable" for guests as possible.

"There are some limitations. We know that up front," Thornton said. "The ship still does not have power. We only have one functioning elevator aboard."

Click here for photos of the stranded ship at sea.

The passengers were achingly close to port about noon today as the ship began to enter the channel and proceed to the cruise terminal. At 1 p.m., the lead tow boat had a tow gear break, so a spare tug boat that was on standby had to be sent in to replace it.

But once the second tug was in position and the lines were re-set, the towing resumed only briefly before the tow line snapped.

"We had to replace that tow line, so the ship did not begin progressing back into the cruise terminal until 2 p.m.," Thornton said

Passengers desperate to get off the vessel waved at media helicopters that flew out to film the ship and passenger Rob Mowlam told ABCNews.com by phone today that most of the passengers on board were "really upbeat and positive."

Nevertheless, when he gets off Mowlam said, "I will probably flush the toilet 10 times just because I can."

Mowlam, 37, got married on board the Triumph Friday and said he and his wife, Stephanie Stevenson, 27, haven't yet thought of redoing the honeymoon other than to say, "It won't be a cruise."

Alabama State Port Authority Director Jimmy Lyons said that with powerless "dead ships" like the Triumph, it is usually safer to bring them in during daylight hours, but, "Once they make the initial effort to come into the channel, there's no turning back."

"There are issues regarding coming into the ship channel and docking at night because the ship has no power and there's safety issues there," Richard Tillman of the Mobile Bay Convention and Visitors Bureau told ABCNews.com.

When asked if the ship could be disembarked in the dark of night, Tillman said, "It is not advised. It would be very unusual."

Thornton denied the rumors that there was a fatality on the ship. He said that there was one illness early on, a dialysis patient, but that passenger was removed from the vessel and transferred to a medical facility.

The U.S. Coast Guard was assisting and there were multiple generators on board. Customs officials were to board the ship while it was being piloted to port to accelerate the embarkation, officials said.

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