Third world is swamped with fake TB drugs: study

 

PARIS: Africa, India and other developing countries are awash in fake or sub-standard drugs for tuberculosis, fuelling the rise of treatment-resistant strains of TB, according to a survey published on Tuesday.

Investigators in the United States asked local people in 19 cities in 17 countries to purchase isoniazid and rifampicin, the frontline antibiotics for TB, from a private-sector pharmacy.

The samples were then examined by chromatography, a technique that detects chemical signature, for their active ingredient.

They were also tested for disintegration, to see if they properly broke up in water at body temperature within 30 minutes.

Out of 713 samples, 9.1 percent failed these basic quality control tests, according to the probe, published in the International Journal of Tuberculosis and Lung Disease.

Around half of the failed samples had zero active ingredients, "making them likely to contribute to drug resistance," it said.

Resistance to TB drugs develops when treatment fails to kill the bacteria that causes it -- either because the patient fails to follow their prescribed dosages or, as in this case, the drug doesn't work.

It can also be contracted through rare forms of the disease that are directly transmissible from person to person.

Dud drugs were manufactured by legitimate companies and criminal fraudsters, said the report.

The pharmacies where the drugs were purchased were in Luanda, Angola; Sao Paulo, Brazil; Beijing, China; Lubumbashi, Democratic Republic of Congo; Cairo, Egypt; Addis Ababa, Ethiopia; Accra, Ghana; Chennai, Delhi and Kolkata, India; Nairobi, Kenya; Lagos, Nigeria; Moscow, Russia; Kigali, Rwanda; Dar-es-Salaam, Tanzania; Bangkok, Thailand; Istanbul, Turkey; Kampala, Uganda; and Lusaka, Zambia.

The failure rate was 16.6 percent in Africa, 10.1 percent in India and 3.9 percent in Brazil, China, Thailand, Turkey and Russia.

Nearly nine million people around the world have TB, including more than 400,000 with a multidrug-resistant form of the disease, according to estimates for 2011 compiled by the World Health Organisation (WHO).

TB is one of the world's deadliest diseases. It is spread from person to person through the air and usually affects the lungs, but it can also affect other parts of the body such as the brain and kidneys.

-AFP/gn

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Microsoft and Huawei debut Windows Phone for Africa

New Huawei Windows Phone, called Huawei 4Afrika, to be introduced in Africa.

(Credit:
Microsoft)

Microsoft and Huawei announced today that they're partnering to bring a new Windows Phone to Africa. The two companies are targeting the continent, which is one of the fastest growing technology markets in the world but has seen few smartphones to date and whose majority of users still rely on feature phones.

"We believe there has never been a better time to invest in Africa and that access to technology -- particularly cloud services and smart devices -- can and will serve as a great accelerator for African competitiveness," president of Microsoft International Jean-Philippe Courtois said today in a statement.

Dubbed Huawei 4Afrika, the smartphone will be the first in a series of devices being created for the region. The phone is expected to roll out in Angola, Egypt, Ivory Coast, Kenya, Morocco, Nigeria, and South Africa later this month.

Microsoft is focusing on Africa and it's population of more than 1 billion to get a stronger hold on the smartphone market. The company said that more than 90 percent of all the phones sold in Kenya and Nigeria are feature phones. Besides Huawei, Microsoft has also worked with HTC, Samsung, and Nokia in developing Windows Phone devices for the continent.

Huawei 4Afrika is similar to the Ascent W1, which Huawei debuted at CES. It has a 4-inch 480 x 800 display, dual-core 1.2 GHz Snapdragon processor, front- and rear-facing cameras, and 4GB of internal storage. The device is available in blue, red, black, and white. It comes preloaded with custom apps made by African developers for local consumers.

Besides giving users access to apps, the smartphone is also expected to be one of the primary ways that people will be able to access the Internet. The smartphone is intended for middle-income users, such as students, small-business owners, and developers. According to The New York Times, it will cost $150.

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Space Pictures This Week: A Space Monkey, Printing a Moon Base

Illustration courtesy Foster and Partners/ESA

The European Space Agency (ESA) announced January 31 that it is looking into building a moon base (pictured in an artist's conception) using a technique called 3-D printing.

It probably won't be as easy as whipping out a printer, hooking it to a computer, and pressing "print," but using lunar soils as the basis for actual building blocks could be a possibility.

"Terrestrial 3-D printing technology has produced entire structures," said Laurent Pambaguian, head of the project for ESA, in a statement.

On Earth, 3-D printing, also known as additive manufacturing, produces a three-dimensional object from a digital file. The computer takes cross-sectional slices of the structure to be printed and sends it to the 3-D printer. The printer bonds liquid or powder materials in the shape of each slice, gradually building up the structure. (Watch how future astronauts could print tools in space.)

The ESA and its industrial partners have already manufactured a 1.7 ton (1.5 tonne) honeycombed building block to demonstrate what future construction materials would look like.

—Jane J. Lee

Published February 4, 2013

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Sarai Sierra's 2 Young Boys Don't Know Mom's Dead

The two young sons of slain New York mom Sarai Sierra are under the impression that their father has gone to Turkey to bring their mother home - alive.

Sierra, whose battered body was found near a highway in Istanbul over the weekend, was the mother of two boys aged 9 and 11.

Steven Sierra, who went to Istanbul in search of his wife after she disappeared nearly two weeks ago, told his children that he was going to Turkey to bring their mom home.

"The father will be speaking to them and it's something that's going to be hard and he's going to be talking to them when he comes back," Betsy Jimenez, the mother of Sarai Sierra, said today during a family news conference.

State Representative Michael Grimm said Steven Sierra's biggest concern is telling his children that mom's not coming home.

"It's going to be the hardest thing he's ever going to have to do in his life," said Grimm, who added that the Staten Island family isn't sure when Steven Sierra will be able to bring home his wife's body.

An autopsy was completed Sunday on Sarai Sierra, 33, but results aren't expected for three months. Turkish officials however said she was killed by at least one fatal blow to her head.

A casket holding the Staten Island mother was carried through alleyways lined with spice and food stalls to a church, where the casket remained on Monday.

Turkish police hope DNA samples from 21 people being questioned in the case will be key to finding the perpetrators, the Associated Press reported, according to state run media.

Sarai Sierra's Body Found: Missing New York Mom Found in Turkey Watch Video

Body Found in Search for Missing Mother in Turkey Watch Video

Vanished Abroad: US Woman Missing in Turkey Watch Video

Earlier this week, it was also reported that Turkish police are speaking to a local man who was supposed to meet Sierra the day she disappeared, but he said she never showed.

After an intense search for Sierra that lasted nearly two weeks, her body was found Saturday near the ruins of some ancient city walls and a highway. Sierra was wearing the same outfit she was seen wearing on surveillance footage taken at a food court and on a street the day she vanished, Istanbul Police Chief Huseyin Capkin said.

Sierra's body was taken to a morgue, Capkin said, and was identified by her husband.

It did not appear she had been raped or was involved in any espionage or trafficking, Capkin said.

Betsy Jimenez said Monday that her family has many unanswered questions such as what happened to her daughter after she left her hotel room to go and take photographs of a famous bridge.

"They're still investigating so they might think it might be a robbery, but they're not sure," said Jimenez.

Sierra, who had traveled to Istanbul on Jan. 7 to practice her photography hobby, was last heard from on Jan. 21, the day she was due to board a flight home to New York City.

Dennis Jimenez, Sierra's father, told reporters Monday that he didn't want her to go on the trip.

"I didn't want her to go. But, she wanted to go because this was an opportunity for her to sightsee and pursue her photography hobby because Turkey was a land rich with culture and ancient history and she was fascinated with that," said Jimenez.

While in Istanbul, Sierra would Skype with her family and friends daily, telling them about how amazing the culture was.

Sierra's best friend Maggie Rodriguez told ABC News that she was forced to pull out of the trip at the last minute because she couldn't afford it. That's why Sierra traveled alone.

Her husband, Steven Sierra, and brother, David Jimenez, traveled to Istanbul last Sunday to meet with American and Turkish officials and push the search forward.

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Bug protects itself by turning its environment to gold

Mythical King Midas was ultimately doomed because everything he touched turned to gold. Now, the reverse has been found in bacteria that owe their survival to a natural Midas touch.

Delftia acidovorans lives in sticky biofilms that form on top of gold deposits, but exposure to dissolved gold ions can kill it. That's because although metallic gold is unreactive, the ions are toxic.

To protect itself, the bacterium has evolved a chemical that detoxifies gold ions by turning them into harmless gold nanoparticles. These accumulate safely outside the bacterial cells.

"This could have potential for gold extraction," says Nathan Magarvey of McMaster University in Hamilton, Ontario, who led the team that uncovered the bugs' protective trick. "You could use the bug, or the molecules they secrete."

He says the discovery could be used to dissolve gold out of water carrying it, or to design sensors that would identify gold-rich streams and rivers.

The protective chemical is a protein dubbed delftibactin A. The bugs secrete it into the surroundings when they sense gold ions, and it chemically changes the ions into particles of gold 25 to 50 nanometres across. The particles accumulate wherever the bugs grow, creating patches of gold.

Deep purple gold

But don't go scanning streams for golden shimmers: the nanoparticle patches do not reflect light in the same way as bigger chunks of the metal – giving them a deep purple colour.

When Magarvey deliberately snipped out the gene that makes delftibactin A, the bacteria died or struggled to survive exposure to gold chloride. Adding the protein to the petri dish rescued them.

The bacterium Magarvey investigated is one of two species that thrive on gold, both identified a decade or so ago by Frank Reith of the University of Adelaide in Australia. In 2009 Reith discovered that the other species, Cupriavidus metallidurans, survives using the slightly riskier strategy of changing gold ions into gold inside its cells.

"If delftibactin is selective for gold, it might be useful for gold recovery or as a biosensor," says Reith. "But how much dissolved gold is out there is difficult to say."

Journal reference: Nature Chemical Biology, DOI: 10.1038/NCHEMBIO.1179

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India's ex-Olympics boss pleads not guilty in graft trial

NEW DELHI: India's former Olympics chief pleaded not guilty in court on Monday to an array of corruption charges related to his handling of the chaotic Delhi Commonwealth Games in 2010.

Suresh Kalmadi, a lawmaker for the ruling Congress party, faces charges of criminal conspiracy, forgery, abuse of office and intimidation over a contract awarded to Swiss Timing, which is part of the Swatch luxury goods empire.

Kalmadi and seven others pleaded not guilty in written statements submitted to a special court set up to try the suspects over the massively over-budget Delhi event. They face a maximum sentence of life imprisonment.

Also facing charges are Kalmadi's deputy during the Commonwealth Games, Lalit Bhanot, who has since been elected number two in the Indian Olympic Association.

The Delhi Games organising committee's director-general V.K. Verma, procurement director Surjit Lal, sports director A.S.V. Prasad, treasurer M. Jayachandran and three others are also on trial.

The next hearing was set for February 20.

-AFP/ac

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Surface Pro lands at Microsoft Store

Microsoft Surface Pro is now on display at the Century City Microsoft Store in Los Angeles.

(Credit:
Brooke Crothers)

LOS ANGELES -- The Surface Pro has arrived early at Microsoft stores.

Locations, such as the store near Beverly Hills, Calif., now have the Pro -- slated to go on sale this Saturday -- on display and available for anyone to use.

So, I spent about an hour with Pro and came away impressed. More impressed than I was initially with Surface RT.

In a word, smooth. In two words, silky smooth. In the limited time I used it, I experienced no lag or stuttering on graphics-intensive sites and videos. And when I used
Microsoft Office in desktop mode (which was installed on the Pro I used) everything was snappy. Really snappy.

The Intel Ivy Bridge chip paired with a PC-class solid-state drive (and 4GB of memory) makes all the difference.

And the 10.6 -inch display at 1,920x1,080 resolution is a stunner. (That's over 2 million pixels at 200 pixels per inch, for those keeping track.)

To me, the resolution looked pretty much the same as on my Retina
iPad 4. Yes, I know, the iPad 4 has a higher pixel density but text was highly resolved (see photo below) on the Pro much like the Retina iPad.

And if all of that sounds appealing to you, you can reserve one. A Microsoft store sales rep will take your name and e-mail address and then hand you a reservation card (see photo below).

Update: Video added at bottom. Just a quick scrolling clip.

Typing with the Pro on my lap. Note, you can also use it on your lap with the stand extended but it felt more comfortable for me flat.

(Credit:
Brooke Crothers)

Text is well resolved and looks pretty much like it does on my iPad 4 -- though display aficionados may dispute that. Note that the wave and grid patterns are a photo artifact, not what you actually see.

(Credit:
Brooke Crothers)

Surface Pro's Metro screen.

(Credit:
Brooke Crothers)

My Surface Pro reservation card. I was told to bring it on Saturday -- when Surface Pro goes on sale.

(Credit:
Brooke Crothers)

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Pictures We Love: Best of January

Photograph by Dieu Nalio Chery, AP

The magnitude 7 earthquake that struck near Port au Prince, Haiti, in January 2010 so devastated the country that recovery efforts are still ongoing.

Professional dancer Georges Exantus, one of the many casualties of that day, was trapped in his flattened apartment for three days, according to news reports. After friends dug him out, doctors amputated his right leg below the knee. With the help of a prosthetic leg, Exantus is able to dance again. (Read about his comeback.)

Why We Love It

"This is an intimate photo, taken in the subject's most personal space as he lies asleep and vulnerable, perhaps unaware of the photographer. The dancer's prosthetic leg lies in the foreground as an unavoidable reminder of the hardships he faced in the 2010 earthquake. This image makes me want to hear more of Georges' story."—Ben Fitch, associate photo editor

"This image uses aesthetics and the beauty of suggestion to tell a story. We are not given all the details in the image, but it is enough to make us question and wonder."—Janna Dotschkal, associate photo editor

Published February 1, 2013

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Super Bowl XLVII: Ravens Hang On, 34-31

Chris Graythen/Getty Images

11:11 p.m. ET: Well, that’s it for the live blog. The game is over, but there’s still a lot for football fans to talk about – lots of missed chances, maybe or maybe not blown calls or no-calls, and, in the end, an epic win for the Baltimore Ravens.

11:06 p.m. ET: First Lady Michelle Obama tweeted her congratulations to the Ravens: “Great game! Congrats to the @Ravens. See you at the White House! -mo”

11:01 p.m. ET: MVP Joe Flacco says this game is emblematic of the city of Baltimore, before handing the Lombardi trophy to Ray Lewis, who says, “when God is for you, who can be against you?”

RELATED: Almighty Referee, God on Side Lines at the Big Game

11:00 p.m. ET: John Harbaugh says facing his brother in this game was the hardest thing he’s ever done. He says he told him he loved him when they met on the field after the game, and Jim congratulated him.

Dave Martin/AP Photo

10:58 p.m. ET: The Ravens made the playoffs for the last 5 seasons – and this is the first Super Bowl win since 2000.

10:57 p.m. ET: Super Bowl XX MVP Richard Dent carries in Vince Lombardi trophy.

10:54 p.m. ET: Lots of things this game will be remembered for: Harbowl, Ray Lewis final victory, incredible performance by MVP Joe Flacco, Beyonce halftime show, and the 34 minute power outage.

Chris Graythen/Getty Images

10:50 p.m. ET: Tonight’s victory means the Baltimore Ravens are the only NFL team to never lose a Super Bowl in multiple appearances. The 49ers are now 5-1 in Super Bowl appearances.

10:47 p.m. ET: Well, it was an entertaining, intense, instant-classic game, that ends with the Baltimore Ravens’ QB, Joe Flacco named MVP.

10:46 p.m. ET: Lots of audible cursing on the field. “F-bomb” trending nationally on twitter.

10:45 p.m. ET: The Harbaugh brothers meet on the field for the handshake.

10:45 p.m. ET: RAVENS WIN 34-31

10:44 p.m. ET: Another Ravens timeout – the last few seconds of this game are taking a long time. 49ers put up a huge fight, but looks like they’ll fall just short of a miraculous comeback.

10:42 p.m. ET: 4 seconds left in the game after Ravens intentionally take a safety. 34-31 Ravens.

10:40 p.m. ET: Baltimore time out with :12 seconds left.

10:38 p.m. ET: 49ers players on the sidelines looking distraught. And Jim Harbaugh still looks angry about the no -call.

10:37 p.m. ET: Niners use their final time out with 1:42 left to play.

10:36 p.m. ET: Ravens get the ball back, and call a timeout with 1:46 remaining in the game.

10:35 p.m. ET: Incomplete pass and Jim Harbaugh is having one of his patented meltdowns on the sidelines.

10:34 p.m. ET: 4th and goal from the 5-yard line after an incomplete pass.

10:33 p.m. ET: 30-second timeout for the 49ers. Good timing, almost a delay of game penalty there.

10:32 p.m. ET: Now 3rd and goal for the 49ers. A stop here would be huge for the Ravens. 1:55 left in the game.

10:29 p.m. ET: Second and goal at the 5-yard line. This game is crazy. 49ers take a timeout at the 2 minute warning.

10:28 p.m. ET: And another quick first down with 2:39 left. First and goal.

10:26 p.m. ET: On 2nd and 10 Kaepernick connects with Crabtree picking up a first down.

10:24 p.m. ET: 49ers pick up seven on the first down. Less than 4 minutes left in the game.

10:22 p.m. ET: 38-yard field goal attempt good for the Ravens. Baltimore up by 5 with 4:19 left in the game. The 49ers still have two timeouts left. 34-29 Ravens.

10:20 p.m. ET: Offsides calls on the defense – five yard penalty makes it 3rd and 2 for the Ravens. Lots of penalties for the 49ers tonight.

10:18 p.m. ET: No matter – Ravens quickly pick up two first downs.

10:17 p.m. ET: Good challenge by Jim Harbaugh. Now 3rd and inches for the Ravens.

10:16 p.m. ET: Super Bowl attendance announced at 71,024. No wonder it got hot during the power outage when the AC cut out.

10:14 p.m. ET: San Francisco challenging first down. Risky move – the team only has two timeouts left with more than 7 minutes left in the game.

10:11 p.m. ET: Pass interference called on the 49ers, automatic first down for the Ravens. Rough week for Chris Culliver.

RELATED: 49ers Chris Culliver to Have Sensitivity Training After Anti-Gay Comments

10:08 p.m. ET: This game could come down to a field goal – many 49ers fans’ biggest fear after Akers’ season.

10:06 p.m. ET: Incomplete throw on the two-point conversion attempt. Kaepernick’s run was the longest rushing touchdown for a quarterback ever in the Super Bowl. 31-29 Ravens.

10:05 p.m. ET: Kaepernick rushes for a touchdown. Niners trying for two-point conversion to try to tie this game up.

Related: ‘Kaepernicking is all the craze after 49ers beat Green Bay

10:04 p.m. ET: TOUCHDOWN 49ERS.

10:03 p.m. ET: And Gore picks up another one. Niners inside the Ravens 20.

10:02 p.m. ET: Randy Moss picks up a first down at the Ravens 39.

9:57 p.m. ET: Incomplete on 3rd and goal. 19-yard field goal attempt is good. 31-23 Ravens.

9:56 p.m. ET: On 1st and goal, Ravens stopped one yard short of the end zone. 2nd and goal.

9:54  p.m. ET: Bernard Pierce not expected to return to the game with a leg injury.

9:51  p.m. ET: First down for the Ravens with an 8-yard gain. Bernard Pierce looks really shaken up after that tackle. Third quarter ends with score still 28-23 Ravens.

9:46  p.m. ET: Scary looking tackle of Jones on the return. Impressive that he kept hold of the ball.

RELATED: Obama: Safety a Concern for Young Football Players

9:44  p.m. ET: Akers gets a redo, and drills it. 17 unanswered points in a 4:10 drive for the 49ers. 28-23 Ravens.

9:43  p.m. ET: Replay of fourth down on a penalty. Ravens player ran into Akers. 4th and 2 for the Niners.

9:43  p.m. ET:  Akers kick no good, but there’s a flag on the field

9:41  p.m. ET: Superdome representative releases statement apologizing for the incident, and NFL statement says authorities are “investigating the cause of the power outage.”

9:40  p.m. ET: Fumble recovered by the 49ers. Momentum definitely swinging the 49ers way.

9:36  p.m. ET: It’s a one score game as Akers drills the extra point. He’s having a surprisingly good game, considering his dismal season. 28-20 Ravens.

9:34  p.m. ET: Frank Gore gets the ball into the end zone, and there’s a player down on the field. 28-19 Ravens.

9:32  p.m. ET: TOUCHDOWN 49ERS.

9:32  p.m. ET: First down by Vernon Davis – this game suddenly got much more interesting. 1st and goal for the Niners.

9:30  p.m. ET: Sack by Admad Brooks – big change of momentum as Ravens punt (badly) – with a big return by the 49ers.

9:28  p.m. ET: Now it’s up to the 49ers defense to keep San Francisco in this game. Jacoby Jones carried the ball to the Ravens 17. His previous carry, intially listed at 109 yards, has been changed to 108 yards, tying the all-time record, not breaking it.

Evan Vucci/AP Photo

9:25  p.m. ET: First touchdown for San Francisco this game, after Kaepernick connects with Crabtree, who runs it into the end zone after an 80-yard drive. 28-13 Ravens.

9:24  p.m. ET: TOUCHDOWN 49ERS.

9:21  p.m. ET: Randy Moss has his first grab of the game, and San Francisco takes a timeout.

9:20  p.m. ET: Great throw by Kaepernick, dropped by Crabtree. 3rd and 8.

9:19  p.m. ET: There it is – a scramble for 15 yards – a first down and some. That’s 36 yards rushing for him now.

9:18  p.m. ET: Kaepernick scrambles for a gain of five. For somebody who has used his legs so successfully this season, he seems really hesitant to try it in this game. 2nd and 5 49ers.

9:15  p.m. ET: Touchback – 49ers will start with the ball at their 20-yard line.

9:12  p.m. ET: Game resumes largely as it played out before the delay. Flacco immediately gets a first down with a 15 yard toss.

9:11  p.m. ET: Not a great start after the delay for the 49ers. A gain of 7, but short of a first down. Andy Lee comes out for the punt.

9:10  p.m. ET: That was a 34 minute delay. No statement from the NFL yet, but that must have been really frustrating for both teams.

READ MORE: Social Media Reacts to the Super Bowl Blackout

9:10  p.m. ET: Apparently, part of the holdup was the electrical equipment on the 49ers side going out with the power. Play set to resume in the next minute or so.

9:08  p.m. ET: Luckily, so far there have been no disturbances reported in the crowd during this blackout delay.

9:05  p.m. ET: Obviously, how each team reacts in the first drive right after this power outage and long delay will be huge. In case you forgot, the 49ers will get the ball at the SF 40 after a Kaepernick sack. 3rd and 13 for the Niners.

9:00  p.m. ET: And there’s already a @SuperbowlLights twitter account.

8:59  p.m. ET: Law enforcement source tells ABC News the power outage is just a technical issue, nothing nefarious. Reporters at the game say they heard a boom in the stadium before the lights went out. Lights slowly coming back on, and players still on the field.

Matt Slocum/AP Photo

8:54  p.m. ET: The AC is apparently also out at the closed stadium, and people say it’s getting hot in there with such a huge crowd and the lights that are on.

8:51  p.m. ET: Considering the score, the fact that this power outage delay may last as long as 20 minutes, and the fact that the halftime show is over, I wonder how many people are tuning out right about now.

8:51  p.m. ET: Power surge to blame, apparently.

8:48  p.m. ET: “Bring Beyonce Back” trending on Twitter now.

READ MORE The Internet Love Beyonce

8:45  p.m. ET: Players trying to stay warmed up on the field, and fans sound like they’re getting really antsy.

8:44  p.m. ET: Commercials cost around $4 million for a 30-second spot, and with these extra commercial breaks, some of them might really be getting their money’s worth.

8:40  p.m. ET:  Sideline reporter says half the lights in the stadium are out, including the scoreboard.

8:40  p.m. ET: 100 million people are expected to be watching the game today…a game that is suddenly not happening as the power cut out during the third quarter.

8:38  p.m. ET: Cut to commercial as the power goes out at the stadium. The game just got even stranger.

8:38  p.m. ET: And the power is out at the Super Dome.

READ MORE: New Orleans in the Spotlight for the Super Bowl

8:37  p.m. ET: Kaepernick sacked for a loss of 6. 3rd and 13.

8:35  p.m. ET: 49ers to start their drive at the 13-yard line.

8:34  p.m. ET:  The biggest deficit ever overcome in the Super Bowl is ten points. It’s been done twice.

Ronald Martinez/Getty Images

8:32  p.m. ET: That was fast (11 seconds to be exact) – a 109-yard kickoff return touchdown by Jacoby Jones. An all-time NFL record. 28-6 Ravens.

8:32  p.m. ET: TOUCHDOWN RAVENS.

8:31  p.m. ET: Back to football. Ravens to receive to start off.

READ MORE: Beyonce Sings Biggest Hits with Surprise Guests

8:27  p.m. ET: First Lady Michelle Obama liked the halftime show. She just tweeted “Watching the #SuperBowl with family & friends.@Beyonce was phenomenal! I am so proud of her! -mo” from her FLOTUS twitter account.

8:22  p.m. ET: And Beyonce ends an impressive and energetic halftime performance with “Halo.”

8:19  p.m. ET: Looks like the DC reunion is over – it was fun while it laster!

Gerald Herbert/AP Photo

8:16  p.m. ET: Destiny’s Child reunion for “Bootylicious!”

8:14  p.m. ET: So many Beyonces!

8:12  p.m. ET: For the halftime performance, there are 135 dancers on the field, and 2,000 fans. And really cool visuals on the stage.

8:10  p.m. ET: Beyonce kicks off the halftime show with “Love on Top” followed by “Crazy in Love.”

8:07  p.m. ET: Here’s what the President and First Lady are eating at their Super Bowl party: Chesapeake Crab Cakes and San Francisco Cioppino Stew with Sourdough Toast. There are also wings, and they’re drinking Anchor Steam and Clipper City beers.

RELATED: Obama Hoping for Close Match in Super Bowl

8:05  p.m. ET: Still, the 49ers rallied from a 17-0 deficit to make it to the Super Bowl so it’s tough to count them out just halfway through.

8:04  p.m. ET: Ravens dominating so far, and it’s not even really close. While the teams take a breather, Beyonce heads to the field for the half time show.

8:00  p.m. ET: First half ends with a Ray Lewis sack. The likely future Hall of Famer is retiring after this game. Strangely enough, his first NFL sack was of Jim Harbaugh – who is currently coaching the 49ers. Also in that game? Randy Moss, who is currently having a rough game for the 49ers.

7:59  p.m. ET: Field goal is Good. 21-6 Ravens at the half.

7:58  p.m. ET: Really looks like the big game jitters are getting to Kaepernick. Ray Lewis sack brings out Akers for a field goal attempt.

7:55  p.m. ET: Fun Fact – Kaepernick was drafted by the Chicago Cubs as a pitcher in 2009. You can see the pitcher still in him with some of these throws.

7:54  p.m. ET: 49ers back in the red zone after a few big gains. They still have two timeouts with less than one minute left in the second quarter.

7:52  p.m. ET: 15-yard penalty and automatic first down for the 49ers on a roughing the passer call.

7:50  p.m. ET: That’s Flacco’s 11th touchdown pass this postseason.

Dave Martin/AP Photo

7:49  p.m. ET: 21 – 3 Baltimore as incredible throw, catch and run lead to a touchdown for the Ravens. 49ers have A LOT of  work to do in the second half.

7:48  p.m. ET: TOUCHDOWN RAVENS.

7:45  p.m. ET: No flag on what looked like offensive pass interference as Culliver breaks up a Flacco long throw, and we hit the two-minute warning.

7:44  p.m. ET: 2nd and 10 for the Ravens with 2 minutes left in the second quarter. The Ravens will be receiving the ball at the beginning of the second half.

7:41  p.m. ET: Kaepernick, who had been noted for his great decision making calls under pressure, is having a rough game so far. At 25 years old, this start is only the tenth pro start of his career.

7:39  p.m. ET: Awesome 9-year-old girl football player Sam Gordon is in the house!

Obtained by ABC News

7:37  p.m. ET: Volkswagen’s controversial ad just aired – here’s Jamaica’s reaction to it.

RELATED: Controversial Volkswagen Super Bowl Ad Gets Viewer Approval

Harry How/Getty Images

7:37  p.m. ET: Gutsy fake field goal call considering the Ravens’ rookie kicker is about as sure a thing as there is for points.

7:36  p.m. ET: Tricky – fake field goal by the Ravens, but short of a first down.

7:34  p.m. ET: Almost an interception by the Niners, but it’s just an incomplete pass by Flacco. 3rd and 9.

7:31  p.m. ET: Another first down for the Ravens.

7:30  p.m. ET: Personal fouls by both teams cancel each other out. Ravens first down at 49ers 38.

7:29  p.m. ET: That interception is evidently the first time a 49ers quarterback has ever been intercepted in the Super Bowl (that’s five previous games). And Reed ties the record with his 9th postseason interception.

Jamie Squire/Getty Images

7:28  p.m. ET: Interception by Baltimore but flag is down and teams fighting on the field.

7:24  p.m. ET: After that commercial about sports fans’ superstitions – here’s an interesting article about when those superstitions cross the line into OCD.

7:22  p.m. ET: Penalties and that fumble killing San Francisco so far. 14-3 Ravens. Ten touchdowns and no interceptions so far this postseason for Flacco.

Harry How/Getty Images

7:22  p.m. ET: TOUCHDOWN BALTIMORE.

7:21  p.m. ET: Automatic first and goal for Ravens after another penalty – a personal foul on 49ers’ Whitner.

7:20  p.m. ET: Flacco connects with Dickson, and a flag is down.

7:19  p.m. ET: While they’re on the subject of Patrick Willis, here’s an interesting story about him and his “brother for life,” the Baltimore’s Michael Oher.

7:17  p.m. ET: Another first down for the Ravens. That’s 4/5 third down conversions for the Ravens so far.

7:16  p.m. ET: Major change of momentum, as Ravens get gain of about 5 after 49ers fumble.

7:12  p.m. ET: Fumble recovered by Ravens. First down for Baltimore.

7:12  p.m. ET: Another first down for the Niners.

7:11  p.m. ET: Another first down on gain of eleven with reception by Davis. Another another small scuffle breaks out. Teams clearly (obviously) passionate.

7:10  p.m. ET: Looks like Davis is okay – gain of 29 yards on great throw from Kaepernick.

7:08  p.m. ET: First Harbaugh parent sightings of the night! They’ve said tonight will be really bittersweet for them.

READ MORE: Super Bowl Bittersweet for Harbaugh Family

7:08  p.m. ET: They may be brothers, but side-by-side comparison of the Harbaugh brothers’ reactions to last play show totally different styles.

7:05  p.m. ET: Flacco sacked with 12 seconds left in quarter.

7:04  p.m. ET: Incomplete throw by Flacco with 17 seconds left in the 1st quarter.

7:03  p.m. ET: Unbelievable throw and catch by Boldin for 31-yards.

7:02  p.m. ET: 3rd and 7 for Ravens after incomplete pass by Flacco.

7:00  p.m. ET: 9-yard gain for the Ravens. Ed Reed in locker room for evaluation.

6:57  p.m. ET: Jacoby Jones returns kick to the 22-yard line. Ravens’ Ed Reed and 49ers’ Vernon Davis both apparently being checked out after Reed hit Davis on previous drive.

Harry How/Getty Images

6:55  p.m. ET: And to the relief of 49ers fans, David Akers field goal attempt is good. 7-3 Ravens.

6:54  p.m. ET: Kaepernick sacked. 49ers going for field goal.

6:53  p.m. ET: Davis out and being worked on by trainers. Second and goal, incomplete in the end zone, off of Crabtree’s hands.

6:52  p.m. ET: Vernon Davis, a super speedy tight end, with another first down on a 24-yard reception from Kaepernick. 1st and goal.

6:51 p.m. ET: And Gore with another first down.

6:50 p.m. ET: Kaepernick scrambles for a gain of seven, 2nd and 3.

6:50 p.m. ET: Kaepernick, who shocked the league with his legs when he took over from Alex Smith, gets a 1st down and then some.

6:49 p.m. ET: Gore gains nine, after having a rough few carries early.

6:48 p.m. ET: Huge, 19-yard game for Michael Crabtree, who broke out this season once Kaepernick took over the starting QB job.

6:46 p.m. ET: Already looking to be a really physical game as scuffle between players breaks out after 49ers loss of two yards.

6:45 p.m. ET: And here’s the GoDaddy commercial everybody has already been talking about – supermodel makes out with Hollywood’s favorite extra.

6:44 p.m. ET: Penalties already hurting the 49ers – big game jitters?

McNamee/Getty Images

6:41 p.m. ET: And the extra point is good. 7-0 Ravens

6:40 p.m. ET: TOUCHDOWN BALTIMORE. Ravens take an early lead with a reception by Anquan Boldin.

6:39 p.m. ET: On 3rd and 9, same thing happens, but flag is down for defensive offsides – five yard penalty and replay of 3rd down.

6:39 p.m. ET: Given some time, Flacco throws ball beyond end zone for an incompletion on 2nd and 9.

6:38 p.m. ET: Ravens QB, Joe Flacco, known for his exceptionally strong arm, gets the ball to Torrey Jones at the SF 19.

6:37 p.m. ET: And a first down for the Ravens from SF 39.

6:36 p.m. ET: Better start for the Ravens, who pick up eight yards on their first down of the game.

6:36 p.m. ET: And the first drive of the game goes nowhere; Andy Lee punts on 4th down, and Jacoby Jones returns to near the 50-yard line.

6:34 p.m. ET: On first and 15, no gain for 49ers all-time leading rusher, Frank Gore.

6:33 p.m. ET: Five yard penalty for the 49ers for illegal formation.

6:32 p.m. ET: Kaepernick connects with Vernon Davis for a gain of 20, but a flag is down.

6:31 p.m. ET: Here we go – 49ers start the first drive at the 20-yard line.

6:28 p.m. ET: Ravens chose heads, and elected to defer their choice until the second half. 49ers to receive at kickoff.

6:27 p.m. ET: Newest members of the Pro Football Hall of Fame join the team captains for the coin toss.

6:22 p.m. ET: Alicia Keys performs the Star Spangled Banner, wearing a red dress and playing a white piano at the 50-yard line.

WATCH: Alicia Keys Sings ‘The Star-Spangled Banner’

6:21 p.m. ET: Joint Armed Forces Color Guard present the flags.

6:20 p.m. ET: Hudson wearing a green ribbon in honor of the victims of the Sandy Hook school shooting while performing with the students.

Jamie Squire/Getty Images

6:19 p.m. ET: In a touching performance, Sandy Hook Elementary School students perform “America the Beautiful,” with Jennifer Hudson.

WATCH: Jennifer Hudson, Sandy Hook Students Perform “America the Beautiful”

6:18 p.m. ET: Jason Witten wins the 2012 Walter Payton NFL Man of the Year Award.

6:12 p.m. ET: And out come the 49ers.

6:11 p.m. ET: The Ravens players are introduced in the stadium to a raucous crowd.

6:09 p.m. ET: And another historic first tonight – the two head coaches are brothers, born just 15 months apart. John Harbaugh, 50, is in his fifth season as the Baltimore Ravens head coach, and has won playoff games in each of his previous seasons. Jim Harbaugh, 49, is in his second season as head coach of the San Francisco 49ers, leading his team to the playoffs both seasons.

6:05 p.m. ET: The San Francisco 49ers are going for their 6th Lombardi trophy, which would tie them for the most championships ever with the Pittsburgh Steelers. The Baltimore Ravens are trying for their second Super Bowl victory. Neither team has ever lost a Super Bowl game – and at the end of the night, there will only be one team left in the NFL to have never lost a Super Bowl game.

6:00 p.m. ET: It’s here – the biggest spectacle in American sports, the Super Bowl. We’ll be covering the game, performances and, of course, the commercials right here.

It’s been an incredible season so far, and everything has led up to tonight’s game in New Orleans, where the NFC Champion San Francisco 49ers face the AFC Champion Baltimore Ravens in Super Bowl XLVII. Keep refreshing for the latest updates throughout what promises to be a great game.

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Two worms, same brains – but one eats the other

IF TWO animals have identical brain cells, how different can they really be? Extremely. Two worm species have exactly the same set of neurons, but extensive rewiring allows them to lead completely different lives.

Ralf Sommer of the Max Planck Institute for Developmental Biology in Tübingen, Germany, and colleagues compared Caenorhabditis elegans, which eats bacteria, with Pristionchus pacificus, which hunts other worms. Both have a cluster of 20 neurons to control their foregut.

Sommer found that the clusters were identical. "These species are separated by 200 to 300 million years, but have the same cells," he says. P. pacificus, however, has denser connections than C. elegans, with neural signals passing through many more cells before reaching the muscles (Cell, doi.org/kbh). This suggests that P. pacificus is performing more complex motor functions, says Detlev Arendt of the European Molecular Biology Laboratory in Heidelberg, Germany.

Arendt thinks predators were the first animals to evolve complex brains, to find and catch moving prey. He suggests their brains had flexible wiring, enabling them to swap from plant-eating to hunting.

This article appeared in print under the headline "Identical brains, but one eats the other"

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