Quadruple DNA helix discovered in human cells

Sixty years after James Watson and Francis Crick established that DNA forms a double helix, a quadruple-stranded DNA helix has turned up.

Quadruple helices that intertwine four, rather than two, DNA strands had been made in the laboratory, but were regarded as curiosities as there was no evidence that they existed in nature. Now, they have been identified in a range of human cancer cells.

The four-stranded packages of DNA, dubbed G-quadruplexes, are formed by the interaction of four guanine bases that together form a square. They appear to be transitory structures, and were most abundant when cells were poised to divide. They appeared in the core of chromosomes and also in telomeres, the caps on the tips of chromosomes that protect them from damage.

Because cancer cells divide so rapidly, and often have defects in their telomeres, the quadruple helix might be a feature unique to cancer cells. If so, any treatments that target them will not harm healthy cells.

"I hope our discovery challenges the dogma that we really understand DNA structure because Watson and Crick solved it in 1953," says Shankar Balasubramanian of the University of Cambridge, UK.

Tagged with antibodies

Balasubramanian's team identified the four-stranded structures in cancer cells with the help of an antibody that attaches exclusively to G-quadruplexes. To stop them from unravelling into the ordinary DNA, they exposed the cells to pyridostatin, a molecule that traps quadruple helices wherever they form.

This enabled the researchers to count how many formed at each stage of cell multiplication. The G-quadruplexes were most abundant in the "S-phase" – when cells replicate their DNA just prior to dividing.

"I expect they will also exist in normal cells, but I predict that there will be differences with cancer cells," says Balasubramanian. His hunch is that the G-quadruplexes are triggered into action by chaotic genomic mutations and reorganisations typical of cancerous or precancerous cells.

"This research further highlights the potential for exploiting these unusual DNA structures to beat cancer, and the next part of this is to figure out how to target them in tumour cells," says Julie Sharp of Cancer Research UK, which funded the research.

Another important question that Balasubramanian's and other teams will try to answer is whether G-quadruplexes play a role in embryo development, and whether such a role is mistakenly reactivated in cancer cells. "We plan to find out whether the quaduplexes are a natural nuisance, or there by design," he says.

Journal reference: Nature Chemistry, DOI: 10.1038/NCHEM.1548

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Tennis: Kuznetsova upsets Wozniacki at Australian Open

MELBOURNE: Two-time Grand Slam winner Svetlana Kuznetsova upset Danish 10th seed and ex-world number one Caroline Wozniacki in a tense three-set battle to make the Australian Open last eight on Monday.

The experienced Russian won 6-2, 2-6, 7-5 and will meet either top seed Victoria Azarenka or Russian Elena Vesnina in the quarter-finals.

It was a courageous win by Kuznetsova, who at 75 is the lowest ranked player left in the tournament after an injury to her right knee forced her to miss a big chunk of 2012, spending two months on crutches.

The injury meant she missed all post-Wimbledon events last year including the US Open, which ended her streak of 40 straight Grand Slam appearances dating back to 2002 at Flushing Meadow.

But Kuznetsova, who won the 2004 US Open and 2009 French Open, said she was feeling fresh again and delighted to be in the quarter-finals.

"I'm really happy with the result because in the second set I got stuck a bit," she said. "But I came out fighting in the third, and it's great.

"After 10 years of travelling I was getting tired," she added of her time on tour. "But I'm feeling fresh again and very happy to be in the quarter-finals because I struggled last year."

It was Wozniacki who was struggling on Monday. Her preparations for Melbourne were hurt by going out early at both the Brisbane and Sydney International tournaments, and her lacklustre form continued in Melbourne.

It was Kuznetsova who knocked her out of Sydney in the second round and while both players held their opening serves, the Russian put the Dane under pressure with some aggressive groundstrokes in the third game.

She won a crucial advantage on the second break point to go 2-1 ahead and consolidated the break by holding serve.

Kuznetsova kept pressing and got a second break in the seventh game when Wozniacki smashed a forehand into the net. She served out for the set but against the run of play, Wozniacki broke for a 2-0 lead in the second set.

The Russian lost her momentum and the Dane pushed on to get another break and take the set in 33 minutes.

It set up a tense decider and the Russian came out refreshed, taking a break for 2-1 with Wozniacki's frustration clear as she slammed her racquet to the ground.

The Dane dug deep to immediately break back as Kuznetsova lashed a forehand wide. The set became a battle with each player desperately trying to outsmart the other.

Kutznetsova finally got the breakthrough when Wozniacki netted a forehand on her serve to hand the Russian a 5-4 lead and she served out for the match.

- AFP/al

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Where to watch Obama's inauguration online

President Obama was sworn in for his second term today in a quiet ceremony at the White House. But it was a simple prelude to the festivities that will take place tomorrow when Obama and Vice President Joe Biden are sworn in outside of the U.S. Capital before hundreds of thousands of spectators -- and countless more who will be tuning in online to watch the event.

The last presidential inauguration ceremony in 2009 was considered by many to be the most interactive ever. But thanks to multimedia content -- including the return of high-resolution satellite imagery from GeoEye -- we may see just as many innovative forms of coverage for this year's event, even though this one is expected to be more low-key.

The public swearing-in ceremony begins at 11:30 a.m. ET, with the official event happening at 11:55 a.m.

Here's just a partial list of where to tune in. Feel free to add to it in the comments below.

• The 2013 Presidential Inaugural Committee will be hosting a live stream of the swearing-in ceremony starting at 11:30 a.m. ET, as well as live video of the inaugural parade and the Commander-in-Chief's Ball.

• The Wall Street Journal will be presenting the inauguration live at 11 a.m ET. It will be anchored by Washington bureau chief Gerald F. Seib, Wendy Bounds and Simon Constable from its New York studios. You can watch it on multiple platforms including WSJ Live, YouTube, Hulu, and Ustream.

• CBS News, our sister site, will be offering live coverage on TV and the Web starting at 10 a.m. ET. The site will also feature live coverage of related events, interactive slide shows, and analysis of Obama's first term and what's ahead in his next term.

• NBCNews.com and the NBC Politics app, which is available on the iPhone, iPad, or iPod Touch, will carry live streams of NBC News' coverage starting at 10 a.m. ET.

• C-SPAN's online live coverage of the inauguration starts at 7 a.m. ET and will include the swearing in, followed by the president's address, the inaugural luncheon, and the inaugural parade.

• Fox News will offer a live stream of the inaugural address as well as coverage of related events around Washington. Fox's coverage will also be available on Hulu.

• ABC News and Yahoo News have teamed up to produce three feeds of online video coverage across ABCNews.com, Yahoo News, GoodMorningAmerica.com, ABC News' iPad and iPhone apps and ABC News affiliate websites, as well as on the ABC News YouTube channel.

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Attack at Algeria Gas Plant Heralds New Risks for Energy Development

The siege by Islamic militants at a remote Sahara desert natural gas plant in Algeria this week signaled heightened dangers in the region for international oil companies, at a time when they have been expanding operations in Africa as one of the world's last energy frontiers. (See related story: "Pictures: Four New Offshore Drilling Frontiers.")

As BP, Norway's Statoil, Italy's Eni, and other companies evacuated personnel from Algeria, it was not immediately clear how widely the peril would spread in the wake of the hostage-taking at the sprawling In Amenas gas complex near the Libyan border.

Map by National Geographic

Algeria, the fourth-largest crude oil producer on the continent and a major exporter of natural gas and refined fuels, may not have been viewed as the most hospitable climate for foreign energy companies, but that was due to unfavorable financial terms, bureaucracy, and corruption. The energy facilities themselves appeared to be safe, with multiple layers of security provided both by the companies and by government forces, several experts said. (See related photos: "Oil States: Are They Stable? Why It Matters.")

"It is particularly striking not only because it hasn't happened before, but because it happened in Algeria, one of the stronger states in the region," says Hanan Amin-Salem, a senior manager at the industry consulting firm PFC Energy, who specializes in country risk. She noted that in the long civil war that gripped the country throughout the 1990s, there had never been an attack on Algeria's energy complex. But now, hazard has spread from weak surrounding states, as the assault on In Amenas was carried out in an apparent retaliation for a move by French forces against the Islamists who had taken over Timbuktu and other towns in neighboring Mali. (See related story: "Timbuktu Falls.")

"What you're really seeing is an intensification of the fundamental problem of weak states, and empowerment of heavily armed groups that are really well motivated and want to pursue a set of aims," said Amin-Salem. In PFC Energy's view, she says, risk has increased in Mauritania, Chad, and Niger—indeed, throughout Sahel, the belt that bisects North Africa, separating the Sahara in the north from the tropical forests further south.

On Thursday, the London-based corporate consulting firm Exclusive Analysis, which was recently acquired by the global consultancy IHS, sent an alert to clients warning that oil and gas facilities near the Libyan and Mauritanian borders and in Mauritania's Hodh Ech Chargui province were at "high risk" of attack by jihadis.

"A Hot Place to Drill"

The attack at In Amenas comes at a time of unprecedented growth for the oil industry in Africa. (See related gallery: "Pictures: The Year's Most Overlooked Energy Stories.") Forecasters expect that oil output throughout Africa will double by 2025, says Amy Myers Jaffe, executive director of the energy and sustainability program at the University of California, Davis, who has counted 20 rounds of bidding for new exploration at sites in Africa's six largest oil-producing states.

Oil and natural gas are a large part of the Algerian economy, accounting for 60 percent of government budget revenues, more than a third of GDP and more than 97 percent of its export earnings. But the nation's resources are seen as largely undeveloped, and Algeria has tried to attract new investment. Over the past year, the government has sought to reform the law to boost foreign companies' interests in their investments, although those efforts have foundered.

Technology has been one of the factors driving the opening up of Africa to deeper energy exploration. Offshore and deepwater drilling success in the Gulf of Mexico and Brazil led to prospecting now under way offshore in Ghana, Mozambique, and elsewhere. (See related story: "New Oil—And a Huge Challenge—for Ghana.") Jaffe says the Houston-based company Anadarko Petroleum has sought to transfer its success in "subsalt seismic" exploration technology, surveying reserves hidden beneath the hard salt layer at the bottom of the sea, to the equally challenging seismic exploration beneath the sands of the Sahara in Algeria, where it now has three oil and gas operations.

Africa also is seen as one of the few remaining oil-rich regions of the world where foreign oil companies can obtain production-sharing agreements with governments, contracts that allow them a share of the revenue from the barrels they produce, instead of more limited service contracts for work performed.

"You now have the technology to tap the resources more effectively, and the fiscal terms are going to be more attractive than elsewhere—you put these things together and it's been a hot place to drill," says Jaffe, who doesn't see the energy industry's interest in Africa waning, despite the increased terrorism risk. "What I think will happen in some of these countries is that the companies are going to reveal new securities systems and procedures they have to keep workers safe," she says. "I don't think they will abandon these countries."

This story is part of a special series that explores energy issues. For more, visit The Great Energy Challenge.

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Obamas Share the Love, Even for Michelle's Bangs

Jan 20, 2013 10:49pm

(Charles Dharapak/AP Photo)

President Obama used the first public remarks of his second term to address what he called the “most significant” event of this weekend: his wife’s much-talked-about new haircut.

“I love her bangs,” Obama told supporters at an inaugural reception at the National Building Museum. “She looks good. She always looks good.”

First lady Michelle Obama, wearing a black sequined cocktail dress and showcasing her new hairdo, also heaped compliments on her husband.

“Let me tell you, it has just been a true thrill to watch this handsome, charming individual grow into the man and the president that he is,” she said, as she reached out to playfully touch the president’s face, sparking laughter from the crowd.

Praising his compassion and courage, the first lady introduced the president as the “love of her life.”

Obama, who was sworn in for a second term in a small White House ceremony earlier today, kept his remarks short, noting he has another big speech to deliver Monday.

“There are a limited amount of good lines and you don’t want to use them all up tonight,” he joked.

Because the Constitutionally mandated date for the inauguration, Jan. 20, fell on a Sunday this year, the traditional, public ceremony was delayed until Monday.

Saving the best for his official inaugural address, the president instead dedicated the bulk of his remarks to thanking supporters for their hard work and dedication to getting him re-elected.

“You understood this was not just about a candidate; it was not just about Joe Biden or Barack Obama. This was about us, who we are as a nation, what values we cherish, how hard we’re willing to fight to make sure that those values live not just for today but for future generations,” he said.

“All of you here understood and were committed to the basic notion that when we put our shoulders to the wheel of history, it moves… It moves forward. And that’s part of what we celebrate when we come together for inauguration,” he said.

SHOWS: World News

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Earth may be crashing through dark matter walls

Earth is constantly crashing through huge walls of dark matter, and we already have the tools to detect them. That's the conclusion of physicists who say the universe may be filled with a patchwork quilt of force fields created shortly after the big bang.

Observations of how mass clumps in space suggest that about 86 per cent of all matter is invisible dark matter, which interacts with ordinary matter mainly through gravity. The most popular theory is that dark matter is made of weakly interacting massive particles.

WIMPs should also interact with ordinary matter via the weak nuclear force, and their presence should have slight but measurable effects. However, years of searches for WIMPs have been coming up empty.

"So far nothing is found, and I feel like it's time to broaden the scope of our search," says Maxim Pospelov of the University of Victoria in Canada. "What we propose is to look for some other signatures."

Bubbly cosmos

Pospelov and colleagues have been examining a theory that at least some of the universe's dark matter is tied up in structures called domain walls, akin to the boundaries between tightly packed bubbles. The idea is that the hot early universe was full of an exotic force field that varied randomly. As the universe expanded and cooled, the field froze, leaving a patchwork of domains, each with its own distinct value for the field.

Having different fields sit next to each other requires energy to be stored within the domain walls. Mass and energy are interchangeable, so on a large scale a network of domain walls can look like concentrations of mass – that is, like dark matter, says Pospelov.

If the grid of domain walls is packed tightly enough – say, if the width of the domains is several hundred times the distance between Earth and the sun – Earth should pass through a domain wall once every few years. "As a human, you wouldn't feel a thing," says Pospelov. "You will go through the wall without noticing." But magnetometers – devices that, as the name suggests, measure magnetic fields – could detect the walls, say Pospelov and colleagues in a new study. Although the field inside a domain would not affect a magnetometer, the device would sense the change when Earth passes through a domain wall.

Dark matter walls have not been detected yet because anyone using a single magnetometer would find the readings swamped by noise, Pospelov says. "You'd never be able to say if it's because the Earth went through a bizarre magnetic field or if a grad student dropped their iPhone or something," he says.

Network needed

Finding the walls will require a network of at least five detectors spread around the world, Pospelov suggests. Colleagues in Poland and California have already built one magnetometer each and have shown that they are sensitive enough for the scheme to work.

Domain walls wouldn't account for all the dark matter in the universe, but they could explain why finding particles of the stuff has been such a challenge, says Pospelov.

If domain walls are found, the news might come as a relief to physicists still waiting for WIMPs to show up. Earlier this month, for instance, a team working with a detector in Russia that has been running for more than 24 years announced that they have yet to see any sign of these dark matter candidates.

Douglas Finkbeiner of the Harvard-Smithsonian Center for Astrophysics, who was not involved in Pospelov's study, isn't yet convinced that dark matter walls exist. But he is glad that physicists are keeping an open mind about alternatives to WIMPs.

"We've looked for WIMP dark matter in so many ways," he says. "At some point you have to ask, are we totally on the wrong track?"

Journal reference: Physical Review Letters, DOI: 10.1103/PhysRevLett.110.021803

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

All comments should respect the New Scientist House Rules. If you think a particular comment breaks these rules then please use the "Report" link in that comment to report it to us.

If you are having a technical problem posting a comment, please contact technical support.

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Scope to expand health screening programmes for elderly: Koh Poh Koon

SINGAPORE: The People's Action Party (PAP) candidate for the Punggol East by-election Dr Koh Poh Koon said he plans to set up a wellness centre for the elderly to help senior residents age actively.

He said there is scope to expand health screening and preventive programmes for the elderly in the ward.

Dr Koh told reporters that plans are still in early stages but the centre will be built as part of the new Community Centre, to be located near Rivervale Plaza.

He said fundraising for the new centre has reached 50 per cent.

Dr Koh added that he will push forward on this effort if and when he is elected MP for the area.

- CNA/ck

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Memorial service honors Swartz as activist, individual

Perhaps not surprisingly, one of the main threads running through today's memorial service in New York City for tech activist Aaron Swartz was a call to action.

That call arose again and again from varied speakers, and was sounded as one of the final notes of the observance when master of ceremonies Ben Wikler, a political campaigner and friend of Swartz's, announced that the service had come to an end but added, "I hope it's clear this is just the beginning of everything we have to do."

Prior to Wikler's closing remarks, Taren Stinebrickner-Kauffman -- founder of SumOfUs.org, an organization devoted to corporate accountability, and Swartz's partner at the time of his suicide, spelled out what some of that "everything" should be.

A fitting tribute to Swartz, she said, would be for "all of us to go out today and fight to make the world a better place." Specifically, Stinebrickner-Kauffman said, the U.S. Attorney's office in Massachusetts -- which at the time of Swartz's death was prosecuting him for his alleged theft of millions of documents from the Jstor database of academic articles -- must be "held accountable" for what critics have said was its persecution of Swartz.

She said the Massachusetts Institute of Technology, where Swartz accessed the database, "must be sure that it's never again complicit" in the sort of pressure put on Swartz by the government. She said the Computer Fraud and Abuse Act, a mid-1980s antihacking law, must be reformed so "this kind of power" over accused hackers could never again be handed to prosecutors. And she said the entire criminal justice system in the U.S. must be reformed in order to make it truly just.

Stinebrickner-Kauffman also said, in a remark that inspired a roar of approval from the hundreds gathered to remember Swartz -- a champion of open access to information -- that all academic research must be made freely available to everyone, everywhere.

Quinn Norton said she'd come to speak not about the "incredibly accomplished activist" or the "Internet saint," but about "a person who almost never did any of the damn dishes" and who sang to her daughter in the car.

(Credit:
Screenshot by Edward Moyer/CNET)

'Hack the whole world'
More than one appeal for action was aimed at the tech community. Doc Searls -- a fellow at the Center for Information Technology and Society at the University of California, Santa Barbara, and an alumnus fellow of the Berkman Center for Internet and Society at Harvard University -- spoke of how Swartz, a figurehead of the anti-SOPA movement, fought the system. Most geeks, he said, "tend to avoid the legal stuff.... There are so few geeks that go that extra step to protect us.... We need to do the work he started."

Roy Singham, chair of IT consultancy Thoughtworks and a major proponent of open-source software, spoke of Swartz's fear that the "wonderful world of technology" would be "usurped" and end up not being a tool of democracy. He contrasted Swartz with the heads of well-known and moneymaking tech companies, whom he called the "self-aggrandizing ego maniacs" who use technology for the benefit "of the 1 percent."

And Stinebrickner-Kauffman recalled a scene in which Swartz spoke before a group of programmers, wielding a picture of Harry Potter, snapping his fingers, and telling them that they could "do magic," that they could "make the world a better place with programming."

David Segal -- a politician, and executive director of the online organizing group Demand Progress -- said Swartz wanted to change everything: "He was trying to hack the whole world -- in the best possible way."

'Another human being'
But there was room too, among the cries for action, for reflection on Swartz's everyday humanity. Writer and photographer Quinn Norton, a former partner of Swartz's, noted that with his death, Swartz had "left us and entered the realm of mythmaking." She wanted to be sure he was remembered in a multidimensional way, as someone who neglected to do the dishes, who sang to her daughter in the
car, who "was another human being with all the flaws and glories that we all have."

At the same time, however, there seemed to be little doubt on the part of Quinn and the other speakers that the world had lost someone special. As Edward Tufte, the famous writer on information design, put it, Swartz was "marvelously and vigorously different" and there's a scarcity of that in today's world. Perhaps, Tufte said, "we can all be a little more different too."

A video of the service can be viewed on the "Remember Aaron Swartz" Web site. (As of this writing, the audio is garbled during the first few seconds of the archived video, but it quickly rights itself. At this point, too, only the first 40 minutes or so of the service are available for viewing.)

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Attack at Algeria Gas Plant Heralds New Risks for Energy Development

The siege by Islamic militants at a remote Sahara desert natural gas plant in Algeria this week signaled heightened dangers in the region for international oil companies, at a time when they have been expanding operations in Africa as one of the world's last energy frontiers. (See related story: "Pictures: Four New Offshore Drilling Frontiers.")

As BP, Norway's Statoil, Italy's Eni, and other companies evacuated personnel from Algeria, it was not immediately clear how widely the peril would spread in the wake of the hostage-taking at the sprawling In Amenas gas complex near the Libyan border.

Map by National Geographic

Algeria, the fourth-largest crude oil producer on the continent and a major exporter of natural gas and refined fuels, may not have been viewed as the most hospitable climate for foreign energy companies, but that was due to unfavorable financial terms, bureaucracy, and corruption. The energy facilities themselves appeared to be safe, with multiple layers of security provided both by the companies and by government forces, several experts said. (See related photos: "Oil States: Are They Stable? Why It Matters.")

"It is particularly striking not only because it hasn't happened before, but because it happened in Algeria, one of the stronger states in the region," says Hanan Amin-Salem, a senior manager at the industry consulting firm PFC Energy, who specializes in country risk. She noted that in the long civil war that gripped the country throughout the 1990s, there had never been an attack on Algeria's energy complex. But now, hazard has spread from weak surrounding states, as the assault on In Amenas was carried out in an apparent retaliation for a move by French forces against the Islamists who had taken over Timbuktu and other towns in neighboring Mali. (See related story: "Timbuktu Falls.")

"What you're really seeing is an intensification of the fundamental problem of weak states, and empowerment of heavily armed groups that are really well motivated and want to pursue a set of aims," said Amin-Salem. In PFC Energy's view, she says, risk has increased in Mauritania, Chad, and Niger—indeed, throughout Sahel, the belt that bisects North Africa, separating the Sahara in the north from the tropical forests further south.

On Thursday, the London-based corporate consulting firm Exclusive Analysis, which was recently acquired by the global consultancy IHS, sent an alert to clients warning that oil and gas facilities near the Libyan and Mauritanian borders and in Mauritania's Hodh Ech Chargui province were at "high risk" of attack by jihadis.

"A Hot Place to Drill"

The attack at In Amenas comes at a time of unprecedented growth for the oil industry in Africa. (See related gallery: "Pictures: The Year's Most Overlooked Energy Stories.") Forecasters expect that oil output throughout Africa will double by 2025, says Amy Myers Jaffe, executive director of the energy and sustainability program at the University of California, Davis, who has counted 20 rounds of bidding for new exploration at sites in Africa's six largest oil-producing states.

Oil and natural gas are a large part of the Algerian economy, accounting for 60 percent of government budget revenues, more than a third of GDP and more than 97 percent of its export earnings. But the nation's resources are seen as largely undeveloped, and Algeria has tried to attract new investment. Over the past year, the government has sought to reform the law to boost foreign companies' interests in their investments, although those efforts have foundered.

Technology has been one of the factors driving the opening up of Africa to deeper energy exploration. Offshore and deepwater drilling success in the Gulf of Mexico and Brazil led to prospecting now under way offshore in Ghana, Mozambique, and elsewhere. (See related story: "New Oil—And a Huge Challenge—for Ghana.") Jaffe says the Houston-based company Anadarko Petroleum has sought to transfer its success in "subsalt seismic" exploration technology, surveying reserves hidden beneath the hard salt layer at the bottom of the sea, to the equally challenging seismic exploration beneath the sands of the Sahara in Algeria, where it now has three oil and gas operations.

Africa also is seen as one of the few remaining oil-rich regions of the world where foreign oil companies can obtain production-sharing agreements with governments, contracts that allow them a share of the revenue from the barrels they produce, instead of more limited service contracts for work performed.

"You now have the technology to tap the resources more effectively, and the fiscal terms are going to be more attractive than elsewhere—you put these things together and it's been a hot place to drill," says Jaffe, who doesn't see the energy industry's interest in Africa waning, despite the increased terrorism risk. "What I think will happen in some of these countries is that the companies are going to reveal new securities systems and procedures they have to keep workers safe," she says. "I don't think they will abandon these countries."

This story is part of a special series that explores energy issues. For more, visit The Great Energy Challenge.

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Algeria Hostage Crisis Over, One American Dead

After the Algerian military's final assault on terrorists holding hostages at a gas complex, the four-day hostage crisis is over, but apparently with additional loss of life among the foreign hostages.

One American, Fred Buttaccio of Texas, has been confirmed dead by the U.S. State Department. Two more U.S. hostages remain unaccounted for, with growing concern among U.S. officials that they did not survive.

But another American, Mark Cobb of Corpus Christi, Texas is now confirmed as safe. Sources close to his family say Cobb, who is a senior manager of the facility, is safe and reportedly sent a text message " I'm alive."

Inside Algerian Hostage Crisis, One American Dead Watch Video

American Hostages Escape From Algeria Terrorists Watch Video

In a statement, President Obama said, "Today, the thoughts and prayers of the American people are with the families of all those who were killed and injured in the terrorist attack in Algeria. The blame for this tragedy rests with the terrorists who carried it out, and the United States condemns their actions in the strongest possible terms. ... This attack is another reminder of the threat posed by al Qaeda and other violent extremist groups in North Africa."

According to Algerian state media, 32 militants are dead and a total of 23 hostages perished during the four-day siege of the In Amenas facility in the Sahara. The Algerian Interior Ministry also says 107 foreign nationals who worked at the facility for BP and other firms were rescued or escaped from the al Qaeda-linked terrorists who took over the BP joint venture facility on Wednesday.

The Japanese government says it fears "very grave" news, with multiple casualties among the 10 Japanese citizens working at the In Amenas gas plant.

Five British nationals and one U.K. resident are either deceased or unaccounted for in the country, according to British Foreign Minister William Hague. Hague also said that the Algerians have reported that they are still trying to clear boobytraps from the site.

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